Background Periodontitis often causes irrevocable destruction of tooth-supporting tissues and eventually leads to tooth loss. Currently, stem cell-based tissue engineering has achieved a favorable result in regenerating periodontal tissues. Moreover, cell-free therapies that aim to facilitate the recruitment of resident repair cell populations to injured sites by promoting cell mobilization and homing have become alternative options to cell therapy. Main text Cell aggregates (e.g., cell sheets) retain a large amount of extracellular matrix which can improve cell viability and survival rates after implantation in vivo. Electrostatic spinning and 3D bioprinting through fabricating specific alignments and interactions scaffold structures have made promising outcomes in the construction of a microenvironment conducive to periodontal regeneration. Cell-free therapies with adding biological agents (growth factors, exosomes and conditioned media) to promote endogenous regeneration have somewhat addressed the limitations of cell therapy. Conclusion Hence, this article reviews the progress of stem cell-based tissue engineering and advanced strategies for endogenous regeneration based on stem cell derivatives in periodontal regeneration.
Frontiers Regenerative Medicine Technologies to Treat Dental, Oral, and Craniofacial Defects
Functional periodontal regeneration using biomineralized extracellular matrix/stem cell microspheroids - ScienceDirect
Regenerative Therapy of Periodontal Tissue
Rejuvenation Therapy – An Overview
Role of Regenerative Medicine in the Treatment of Diseases
Advances in antimicrobial hydrogels for dental tissue engineering: regenerative strategies for endodontics and periodontics - Biomaterials Science (RSC Publishing) DOI:10.1039/D3BM00719G
Role of Regenerative Medicine in the Treatment of Diseases
A narrative overview of utilizing biomaterials to recapitulate the salient regenerative features of dental-derived mesenchymal stem cells
New insights into nanotherapeutics for periodontitis: a triple concerto of antimicrobial activity, immunomodulation and periodontium regeneration, Journal of Nanobiotechnology